Human Brain Models
Improve confidence in CNS drug discovery.
Nevana Biosystems is developing advanced human stem cell-derived brain models that better replicate the complexity of the human central nervous system.
The Challenge
Better models are needed for better decisions.
Developing therapies for neurological disease remains one of the greatest challenges in drug discovery. Many promising compounds fail during development because existing preclinical models do not fully capture the complexity of the human brain.
For discovery and translational teams, this creates uncertainty when selecting which candidates to progress.
How We're Helping
More human-relevant models for CNS research.
Our research focuses on developing human stem cell-derived brain models that better represent the cellular complexity of the human central nervous system.
By incorporating multiple neural cell types and region-specific biology, these models aim to provide a more representative platform for investigating therapeutic efficacy, mechanism of action and safety than conventional in vitro systems.
Long Term Vision
Helping Researchers Globally to:
Prioritise the most promising therapeutic candidates earlier.
Better understand how compounds behave in human neural tissue.
Reduce reliance on models with limited clinical relevance.
Improve confidence before progressing to costly in vivo and clinical studies.
Human Brain Models
Why Our Models Are Different
Human-Relevant Biology
Stem cell-derived brain models designed to better reflect the complexity of human CNS tissue than conventional cell cultures.
Multicellular Complexity
Platforms incorporating neurons, astrocytes, microglia and vascular components to better represent interactions within the brain.
Comprehensive Readouts
Combining functional and molecular analyses to generate deeper insights into efficacy, mechanism of action and safety.
Region-Specific Brain Models
Developing models of the cortex, hippocampus, ganglionic eminence and choroid plexus to answer specific research questions.
Flexible Research Collaboration
Developing bespoke models and assays tailored to disease biology, therapeutic targets and individual research programmes.
Early Collaboration
If you're exploring more predictive human-relevant models for CNS drug discovery, we'd welcome a conversation about your current challenges and how our research could support future studies.
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Looking for More Predictive Models for CNS Drug Discovery?
Developing therapies for neurological disease remains one of the greatest challenges in drug discovery. Many promising compounds fail during development because existing preclinical models do not fully capture the complexity of the human brain.